Chloroacetyl chloride → 3-[(2-Chloroacetyl)amino]-2,4,6-triiodobenzoic acid

HRID 2258392Notes

Reaction equation

HRID 2258392 reaction equation
[NH2:1][C:2]1[C:3]([I:13])=[C:4]([C:8]([I:12])=[CH:9][C:10]=1[I:11])[C:5]([OH:7])=[O:6].[Cl:14][CH2:15][C:16](Cl)=[O:17]>CC(N(C)C)=O>[Cl:14][CH2:15][C:16]([NH:1][C:2]1[C:3]([I:13])=[C:4]([C:8]([I:12])=[CH:9][C:10]=1[I:11])[C:5]([OH:7])=[O:6])=[O:17]

Participants

4

Reactant 2

HCID 6577Chloroacetyl chlorideHCID 183873-Amino-2,4,6-triiodobenzoic acid

Product 1

HCID 229213943-[(2-Chloroacetyl)amino]-2,4,6-triiodobenzoic acidYield 79%

Reagents, catalysts & solvents 1

HCID 31374DimethylacetamideSolvent

Procedure

According to the procedure described in Example 1, a suspension of 103 g of 3-amino-2,4,6-triiodobenzoic acid (Beil. XIV, 414) (0.2 mol) in 200 ml of DMA is added to 24.8 g of chloroacetyl chloride (0.22 mol). 93.27 g of 3-[(2-chloroacetyl)amino]-2,4,6-triiodobenzoic acid are obtained (0.158 mol).

Sources & evidence

ORD record
ord-fdc99b74eda645c0acb6968de1c590af
Source dataset
uspto-grants-1997_08
Patent number
US05660814

Reaction notes

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