Hydrochloric Acid → HCID 178437427, compound

HRID 2258461Notes

Reaction equation

HRID 2258461 reaction equation
[CH2:1]([C:3]1[N:13]([CH2:14][C:15]2[CH:20]=[CH:19][C:18]([C:21]3[N:22]([CH2:32][CH3:33])[C:23]([CH3:31])=[CH:24][C:25]=3[C:26]3[NH:30][N:29]=[N:28][N:27]=3)=[CH:17][CH:16]=2)[C:6]2=[N:7][C:8]([CH3:12])=[CH:9][C:10]([CH3:11])=[C:5]2[N:4]=1)[CH3:2].[ClH:34]>C(O)C>[ClH:34].[CH2:1]([C:3]1[N:13]([CH2:14][C:15]2[CH:20]=[CH:19][C:18]([C:21]3[N:22]([CH2:32][CH3:33])[C:23]([CH3:31])=[CH:24][C:25]=3[C:26]3[NH:30][N:29]=[N:28][N:27]=3)=[CH:17][CH:16]=2)[C:6]2=[N:7][C:8]([CH3:12])=[CH:9][C:10]([CH3:11])=[C:5]2[N:4]=1)[CH3:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178437426HCID 178437426, compound

Product 1

HCID 178437427HCID 178437427, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a mixture of 2-ethyl-5,7-dimethyl-3-[4-[1-ethyl-5-methyl-3-(1H-tetrazol-5-yl)pyrrol-2-yl]benzyl]-3H-imidazo-[4,5-b]pyridine (3.54 g) and ethanol (18 ml) was added 12N hydrochloric acid (0.8 ml), and the reaction mixture was heated in a boiling bath for a few minutes. The resultant solution was evaporated in vacuo, and the residue was crystallized from a mixture of 1N hydrochloric acid and ethanol to afford 2-ethyl-5,7-dimethyl-3-[4-[1-ethyl-5-methyl-3-(1H-tetrazol-5-yl)pyrrol-2-yl]benzyl]-3H-imidazo-[4,5-b]pyridine hydrochloride (2.38 g). m.p. 246°-248° C.

Workup

  1. temperaturethe reaction mixture was heated in a boiling bath for a few minutes
  2. customThe resultant solution was evaporated in vacuo
  3. customthe residue was crystallized from a mixture of 1N hydrochloric acid and ethanol

Sources & evidence

ORD record
ord-958736ca61db4eb29f31b6e6cf6e4846
Source dataset
uspto-grants-1997_08
Patent number
US05661158

Reaction notes

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