Methylamine → 3-methyl-6-(methylamino)-1-phenylpyrimidine-2,4(1H,3H)-dione
Reaction equation
Cl[C:2]1[N:7]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[C:6](=[O:14])[N:5]([CH3:15])[C:4](=[O:16])[CH:3]=1.[CH3:17][NH2:18]>CC(O)C>[CH3:15][N:5]1[C:4](=[O:16])[CH:3]=[C:2]([NH:18][CH3:17])[N:7]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[C:6]1=[O:14]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 90 °C
Procedure
The obtained 6-chloro-3-methyl-1-phenyluracil (4.26 g, 18 mM) was added to 100 ml of 2-propanol. A 40% aqueous solution of methylamine (17 g, 0.22M) was added to the resulting solution and the mixture was heated at 90° C. for 5 hours while stirring. After being left to cool, a precipitated crystal was obtained by filtration and washed successively with ethanol and water to yield 3-methyl-6-methylamino-1-phenyluracil (yield: 3.71 g, or 89% based on 6-chloro-3-methyl-1-phenyluracil).
Workup
- waitAfter being left
- temperatureto cool
- customa precipitated crystal was obtained by filtration
- washwashed successively with ethanol and water
Sources & evidence
- ORD record
- ord-17c53ece066a49338c8a2388adecf8ee
- Source dataset
- uspto-grants-1997_08
- Patent number
- US05661153
Reaction notes
Loading…