Acetic Acid → N-(10-amino-9-bromo-1,2-dihydro-1-oxobenzo[f]quinazolin-3-yl)pivalamide

HRID 2258657Notes

Reaction equation

HRID 2258657 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[CH:14]=[CH:13][C:12]3[N:11]=[C:10]([NH:15][C:16](=[O:21])[C:17]([CH3:20])([CH3:19])[CH3:18])[NH:9][C:8](=[O:22])[C:7]=3[C:6]=2[C:23]=1[N+:24]([O-])=O.C(O)(=O)C.C(Cl)(Cl)Cl.C(=O)(O)[O-].[Na+]>C(O)C.[Fe].O>[NH2:24][C:23]1[C:6]2[C:7]3[C:8](=[O:22])[NH:9][C:10]([NH:15][C:16](=[O:21])[C:17]([CH3:19])([CH3:20])[CH3:18])=[N:11][C:12]=3[CH:13]=[CH:14][C:5]=2[CH:4]=[CH:3][C:2]=1[Br:1]

Participants

8

Reactant 4

HCID 176Acetic AcidHCID 6212ChloroformHCID 516892Sodium BicarbonateHCID 135838163N-(9-bromo-1,2-dihydro-10-nitro-1-oxobenzo[f]quinazolin-3-yl)pivalamide

Product 1

HCID 135838115N-(10-amino-9-bromo-1,2-dihydro-1-oxobenzo[f]quinazolin-3-yl)pivalamide

Reagents, catalysts & solvents 3

HCID 23925IronCatalystHCID 702EthanolSolventHCID 962WaterSolvent

Procedure

A mixture of N-(9-bromo-1,2-dihydro-10-nitro-1-oxobenzo[f]quinazolin-3-yl)pivalamide (0.8 g, 1.9 mmoles) and iron powder (0.44 g, 7.8 mmoles) in ethanol:glacial acetic acid/1:1 (25 ml) was stirred and heated to reflux under a nitrogen atmosphere for 3 hours. The reaction mixture was poured into chloroform:water/2:1 (150 ml) and neutralized by addition of solid sodium bicarbonate. The chloroform layer was separated, and the aqueous phase was washed twice with chloroform (50 ml each). Combined chloroform layers were dried over sodium sulfate, filtered and evaporated under reduced pressure. The crude product was purified on a silica gel column eluting with chloroform to give N-(10-amino-9-bromo-1,2-dihydro-1-oxobenzo[f]quinazolin-3-yl)pivalamide as a bright yellow solid. (0.66 g, 89%) 1H NMR(DMSO-d6, 200 MHz) δ: 1.27(s, 9H, t-butyl); 6.51(s, 2H, NH2); 7.22(d, J=8.4 Hz, 1H, Ar); 7.51(br d, J=9 Hz, 1H, Ar); 7.72(d, J=8.4 Hz, 1H, Ar); 8.12(d, J=9.0 Hz, 1H, Ar); 11.40(br s, 1H, NH); 12.45(br s, 1H, NH).

Workup

  1. temperatureheated
  2. temperatureto reflux under a nitrogen atmosphere for 3 hours
  3. customThe chloroform layer was separated
  4. washthe aqueous phase was washed twice with chloroform (50 ml each)
  5. dry with materialCombined chloroform layers were dried over sodium sulfate
  6. filtrationfiltered
  7. customevaporated under reduced pressure
  8. customThe crude product was purified on a silica gel column
  9. washeluting with chloroform

Sources & evidence

ORD record
ord-03f063be26a143da837283b4cd6253b8
Source dataset
uspto-grants-1997_08
Patent number
US05661155

Reaction notes

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