反应详情

To a solution of 2-(3-(3-(7-chloroquinolin-2-yl)propyl)phenyl)-1,3-dioxolane from Step 6 (189 mg) in THF (9.5 mL) was added a 1 to 1 mixture of acetic acid and water (6.5 mL). The reaction was heated at 63° for 2 hours. The reaction was diluted with ethyl acetate and the organic layer washed with saturated aqueous solution of sodium bicarbonate. The organic layer was dried over sodium sulfate and evaporated. The residue was co-evaporated once with toluene to afford the title compound.

1. temperatureThe reaction was heated at 63° for 2 hours
2. washthe organic layer washed with saturated aqueous solution of sodium bicarbonate
3. dry with materialThe organic layer was dried over sodium sulfate
4. customevaporated