Water → HCID 19003217, compound

HRID 2259282Notes

Reaction equation

HRID 2259282 reaction equation
Cl.[NH2:2][C@H:3]1[CH2:8][CH2:7][C@H:6]([OH:9])[CH2:5][CH2:4]1.C(N(CC)CC)C.[Cl:17][C:18]1[CH:23]=[CH:22][C:21]([S:24](Cl)(=[O:26])=[O:25])=[CH:20][CH:19]=1.O>C(Cl)(Cl)Cl>[Cl:17][C:18]1[CH:23]=[CH:22][C:21]([S:24]([NH:2][CH:3]2[CH2:8][CH2:7][CH:6]([OH:9])[CH2:5][CH2:4]2)(=[O:26])=[O:25])=[CH:20][CH:19]=1

Participants

6

Reactant 4

HCID 962WaterHCID 73984-Chlorobenzenesulfonyl chlorideHCID 8471TriethylamineHCID 178479278HCID 178479278, compound

Product 1

HCID 19003217HCID 19003217, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent2×

Procedure

To 100 g of trans-4-aminocyclohexanol hydrochloride suspended in 11 of chloroform are added, at 5° C., 184 ml of triethylamine, followed by a solution containing 143 g of 4-chlorophenylsulfonyl chloride in 150 ml of chloroform. After reaction for 2 hours, the reaction mixture is poured onto 500 ml of water. The expected product is obtained by filtration of the precipitate.

Workup

  1. additionare added, at 5° C.
  2. customAfter reaction for 2 hours

Sources & evidence

ORD record
ord-bc1ec3e45362478b88e4c84a40c5c387
Source dataset
uspto-grants-1995_12
Patent number
US05472979

Reaction notes

Loading…