反应详情

3,5-Dimethylbenzyl 2-(1,1-dimethylethoxycarbonylamino)-3-(3-indolyl)propionate (1.0 g) was dissolved in dry tetrahydrofuran (20 ml). Saturated methanolic hydrochloric acid (10 ml) was added and the reaction was stirred for 16 hours. The solvent was removed in vacuo and the residue was recrystallised from ethanol/diethyl ether to yield 3,5-dimethylbenzyl 2-amino-3-(3-indolyl)propionate hydrochloride (0.71 g), m.p. 213°-214° C. 1H NMR (360 MHz D6DMSO) δ11.09 (1H, s), 8.64 (1H, s), 7.51 (1H, d, J=7 Hz), 7.38 (1H, d, J=7 Hz), 7.20 (1H, d, J=2 Hz), 7.10 (1H, t, J=7 Hz), 6.98 (1H, t, J=7 Hz), 6.94 (1H, s), 6.76 (2H, s). Found: C, 66.25; H, 6.67; N, 7.71, C20H22N2O2. HCl. 0.25(H2O) requires C, 66.11; H, 6.52; N, 7.71%.

1. customThe solvent was removed in vacuo
2. customthe residue was recrystallised from ethanol/diethyl ether