反应详情

Ethyl isocyanate (0.13 mL, 1.68 mmole) was added to a solution of (E)-3-(6-aminopyridin-3-yl)-N-methyl-N-(1-methyl-1H-indol-2-ylmethyl)acrylamide (0.27 g, 0.84 mmole) and triethylamine (0.29 mL, 2.1 mmole) in DMF (30 mL) at RT. The reaction was stirred for 6 days, then was concentrated in vacuo, and the residue was diluted with water and extracted with ethyl acetate. The combined organic extracts were washed with brine, dried over Na2SO4, and concentrated. Flash chromatography on silica gel (ethyl acetate) gave the tide compound (80 mg, 24%) as a light yellow solid: MS (ES) m/e 392 (M+H)+.

1. concentrationwas concentrated in vacuo
2. additionthe residue was diluted with water
3. extractionextracted with ethyl acetate
4. washThe combined organic extracts were washed with brine
5. dry with materialdried over Na2SO4
6. concentrationconcentrated