Trifluoroacetic acid → HCID 68829449, compound

HRID 225947Notes

Reaction equation

HRID 225947 reaction equation
[Cl:1][C:2]1[CH:37]=[CH:36][CH:35]=[C:34]([Cl:38])[C:3]=1[C:4]([O:6][CH2:7][C:8](=[O:33])[C@@H:9]([NH:18][C:19]([C:21]1([CH3:32])[O:25][N:24]=[C:23]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[CH2:22]1)=[O:20])[CH2:10][C:11]([O:13]C(C)(C)C)=[O:12])=[O:5].FC(F)(F)C(O)=O>ClCCl>[Cl:38][C:34]1[CH:35]=[CH:36][CH:37]=[C:2]([Cl:1])[C:3]=1[C:4]([O:6][CH2:7][C:8](=[O:33])[C@@H:9]([NH:18][C:19]([C:21]1([CH3:32])[O:25][N:24]=[C:23]([C:26]2[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=2)[CH2:22]1)=[O:20])[CH2:10][C:11]([OH:13])=[O:12])=[O:5]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 68829080HCID 68829080, compound

Product 1

HCID 68829449HCID 68829449, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The compound prepared in Example 1 (44 mg) was dissolved in dichloromethane (2 ml), and trifluoroacetic acid (1 ml) was added at 0□. The mixture was stirred for two hours while it was slowly warmed to room temperature, and then concentrated under reduced pressure to give the title compound (Iaa) in a stoichiometric amount.

Workup

  1. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-346334bf7c244bbd9c3a4d16f7670cca
Source dataset
uspto-grants-2009_07
Patent number
US07557133B2

Reaction notes

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