反应详情

A mixture of 4.28 g (0.02 moles) of 3-(1H-tetrazol-5-yl)-4-oxo-4H-pyrido[1,2-a]pyrimidine; 100 ml of dimethylformamide, 2.76 g (0.02 moles) of anhydrous potassium carbonate and 25 ml (0.04 moles) of methyl iodide was stirred at 75°-80° C. for 1 hour. The yellow suspension gradually dissolved and at the end of the reaction an orange-colored solution was obtained. The warm reaction mixture was filtered, cooled down and the precipitating crystals were collected. 2.3 g (50.4%) of the title compound were obtained, and crystallized from dimethylformamide to obtain white crystals, m.p.: 280°-282° C. (under decomposition).

1. dissolutionThe yellow suspension gradually dissolved and at the end of the reaction an orange-colored solution
2. customwas obtained
3. customThe warm reaction mixture
4. filtrationwas filtered
5. temperaturecooled down
6. customthe precipitating crystals were collected