Methyl iodide → HCID 19001445, compound

HRID 2259559Notes

Reaction equation

HRID 2259559 reaction equation
[NH:1]1[C:5]([C:6]2[C:11](=[O:12])[N:10]3[CH:13]=[CH:14][CH:15]=[CH:16][C:9]3=[N:8][CH:7]=2)=[N:4][N:3]=[N:2]1.[C:17](=O)([O-])[O-].[K+].[K+].CI>CN(C)C=O>[CH3:17][N:1]1[C:5]([C:6]2[C:11](=[O:12])[N:10]3[CH:13]=[CH:14][CH:15]=[CH:16][C:9]3=[N:8][CH:7]=2)=[N:4][N:3]=[N:2]1

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 178515422HCID 178515422, compound

Product 1

HCID 19001445HCID 19001445, compoundYield 50.4%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A mixture of 4.28 g (0.02 moles) of 3-(1H-tetrazol-5-yl)-4-oxo-4H-pyrido[1,2-a]pyrimidine; 100 ml of dimethylformamide, 2.76 g (0.02 moles) of anhydrous potassium carbonate and 25 ml (0.04 moles) of methyl iodide was stirred at 75°-80° C. for 1 hour. The yellow suspension gradually dissolved and at the end of the reaction an orange-colored solution was obtained. The warm reaction mixture was filtered, cooled down and the precipitating crystals were collected. 2.3 g (50.4%) of the title compound were obtained, and crystallized from dimethylformamide to obtain white crystals, m.p.: 280°-282° C. (under decomposition).

Workup

  1. dissolutionThe yellow suspension gradually dissolved and at the end of the reaction an orange-colored solution
  2. customwas obtained
  3. customThe warm reaction mixture
  4. filtrationwas filtered
  5. temperaturecooled down
  6. customthe precipitating crystals were collected

Sources & evidence

ORD record
ord-035ce17429474478b4212ef0c84694cd
Source dataset
uspto-grants-1995_12
Patent number
US05475000

Reaction notes

Loading…