Dimethylformamide → HCID 54409624, compound

HRID 2259564Notes

Reaction equation

HRID 2259564 reaction equation
[NH:1]1[C:5]([C:6]2[C:11](=[O:12])[N:10]3[C:13]([CH3:17])=[CH:14][CH:15]=[CH:16][C:9]3=[N:8][CH:7]=2)=[N:4][N:3]=[N:2]1.[CH3:18]N(C)C=O.C(=O)([O-])[O-].[K+].[K+].CI>O>[CH3:18][N:1]1[C:5]([C:6]2[C:11](=[O:12])[N:10]3[C:13]([CH3:17])=[CH:14][CH:15]=[CH:16][C:9]3=[N:8][CH:7]=2)=[N:4][N:3]=[N:2]1

Participants

6

Reactant 4

HCID 6228DimethylformamideHCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 178423940HCID 178423940, compound

Product 1

HCID 54409624HCID 54409624, compoundYield 66.53%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
80 °C

Procedure

A mixture of 2.3 g of 3- (1H-tetrazol-5-yl) -6-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidine, 50 ml of dimethylformamide, 1.38 g (0.001 mole) of anhydrous potassium carbonate and 2.85 g (0.02 moles) of methyl iodide was stirred at 80° C. for 1 hour. The reaction mixture was cooled to room temperature and diluted with 150 ml of water. The precipitating crystals were collected. 1.61 g (66.53%) of the title compound was obtained, which was crystallized from dimethylformamide, m.p.: 232°-234° C.

Workup

  1. temperatureThe reaction mixture was cooled to room temperature
  2. customThe precipitating crystals were collected

Sources & evidence

ORD record
ord-2e3c3fbef4ce43719b29b41ede54c4d8
Source dataset
uspto-grants-1995_12
Patent number
US05475000

Reaction notes

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