Triethylamine → HCID 19001373, compound

HRID 2259614Notes

Reaction equation

HRID 2259614 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH:12]([C:13]3[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=3)[CH2:11][C:10]([C:20](Cl)=[O:21])=[N:9]2)=[CH:4][CH:3]=1.[NH2:23][C:24]1[CH:25]=[CH:26][C:27]([Cl:30])=[N:28][CH:29]=1.C(N(CC)CC)C>C1COCC1>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[CH:12]([C:13]3[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=3)[CH2:11][C:10]([C:20]([NH:23][C:24]3[CH:29]=[N:28][C:27]([Cl:30])=[CH:26][CH:25]=3)=[O:21])=[N:9]2)=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 793055-Amino-2-chloropyridineHCID 19001400HCID 19001400, compound

Product 1

HCID 19001373HCID 19001373, compoundYield 57.6%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

A solution of 0.9 g of 1-(4-chlorophenyl)-5-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole-3-carbonyl chloride in 10 mL of THF was added to a solution of 0.4 g of 5-amino-2-chloropyridine, 2.0 mL Of triethylamine and 10 mL of THF. The resulting suspension was stirred at room temperature for 2 hours. The solvent was evaporated and the residue was triturated with 10 mL of methanol to afford 0.66 g of the title compound, mp 191°-193° C.

Workup

  1. customThe solvent was evaporated
  2. customthe residue was triturated with 10 mL of methanol

Sources & evidence

ORD record
ord-fd1a426de6834aa9ac7e7cfbacda6ad3
Source dataset
uspto-grants-1995_12
Patent number
US05474998

Reaction notes

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