HCID 15342517, compound → HCID 19001539, compound

HRID 2259655Notes

Reaction equation

[O:1]=[C:2]1[O:6][CH:5]([C:7]2[S:8][C:9]3[CH:15]=[C:14]([N:16]4[CH2:20][CH:19]([CH2:21][O:22][CH3:23])[O:18][C:17]4=[O:24])[CH:13]=[CH:12][C:10]=3[N:11]=2)[CH2:4][CH2:3]1.[H-].C([Al+]CC(C)C)C(C)C>O1CCCC1>[OH:6][CH:5]([C:7]1[S:8][C:9]2[CH:15]=[C:14]([N:16]3[CH2:20][CH:19]([CH2:21][O:22][CH3:23])[O:18][C:17]3=[O:24])[CH:13]=[CH:12][C:10]=2[N:11]=1)[CH2:4][CH2:3][CH2:2][OH:1]

Participants

Conditions

Temperature: -50 °C

Procedure

3.48 g of the 3-[2-(5-oxotetrahydrofuran-2-yl)-benzothiazol-6-yl]-5-methoxymethyl-2-oxazolidinone obtained in the Example 5 was dissolved in 20 ml of anhydrous tetrahydrofuran and the solution was cooled to -50° C. 30 ml of a 1.0M solution of diisobutylaluminum hydride in tetrahydrofuran was added dropwise thereto. After stirring for 30 min followed by ordinary treatment and recrystallization, 2.8 g of 3-[2-(1,4-dihydroxybutyl)benzothiazol-6-yl]-5-methoxymethyl-2-oxazolidinone was obtained.

Workup

customfollowed by ordinary treatment and recrystallization

Sources & evidence

ORD record: ord-3f0db96fad1b4f3a8ca8fa6121e1253b
Source dataset: uspto-grants-1995_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05475014

Reaction notes

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