Benzene → HCID 19001630, compound

HRID 2259775Notes

Reaction equation

HRID 2259775 reaction equation
[CH2:1]=[O:2].[ClH:3].[CH:4]([C:7]1[CH:15]=C[C:10]2[O:11][CH2:12]O[C:9]=2[CH:8]=1)([CH3:6])[CH3:5].[CH:16]1C=CC=CC=1>C(OCC)(=O)C>[Cl:3][CH2:16][C:8]1[C:7]([CH:4]([CH3:5])[CH3:6])=[CH:15][C:1]2[O:2][CH2:12][O:11][C:10]=2[CH:9]=1

Participants

6

Reactant 4

HCID 241BenzeneHCID 313Hydrochloric Acid2×HCID 712FormaldehydeHCID 13934185HCID 13934185, compound

Product 1

HCID 19001630HCID 19001630, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Conditions

Temperature
55 °C

Procedure

A mixture comprising 30 g of 37% formalin, 13 ml of concentrated hydrochloric acid and 100 m l of ethyl acetate was heated to 55° C., while passing hydrochloric acid gas through the mixture. A solution of 7.5 g of 5-isopropyl-1,3-benzodioxole in 20 ml of ethyl acetate was dropwise added to the resulting mixture and the obtained mixture was stirred as such for 2.5 hours and cooled, followed by the addition of benzene. The obtained mixture was washed with water, dried over anhydrous magnesium sulfate and filtered. The filtrate was concentrated to obtain 10.22 g of the title compound as a crude oil.

Workup

  1. temperaturecooled
  2. washThe obtained mixture was washed with water
  3. dry with materialdried over anhydrous magnesium sulfate
  4. filtrationfiltered
  5. concentrationThe filtrate was concentrated

Sources & evidence

ORD record
ord-deaf3a731f2f4bd4987e1acecf9d890f
Source dataset
uspto-grants-1995_12
Patent number
US05475024

Reaction notes

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