反应详情

温度

-10 °C

23.2 g (0.1 mole) of 5,6,7,8-tetrahydro-5,5,8,8-tetramethylnaphthalene-2-carboxylic acid and 18 g (0.15 mole) of thionyl chloride in 75 ml of toluene were heated until hydrogen chloride gas was no longer formed. Thereafter, the mixture was evaporated down, toluene was added several times and the mixture was evaporated down again to remove residual thionyl chloride. The residue was dissolved in 75 ml of isopropanol and added dropwise at from -10° to -15° C. to a solution of 7.4 g (0.23 mole) of hydrazine in 200 ml of isopropanol. The mixture was stirred for 15 minutes at -10° C., 150 ml of water and 50 ml of ether were added and the mixture was stirred again vigorously. The mixture was left to stand overnight, after which the solid was filtered off and the filtrate was extracted with water/ether. The organic phase was washed with water, dried over sodium sulfate and evaporated down. 19.7 g (0.08 mole) of the 5,6,7,8-tetrahydro-5,5,8,8-tetramethylnaphthalene-2-carboxylic hydrazide remaining as the residue were dissolved in 100 ml of dry tetrahydrofuran. A solution of 13.5 (0.088 mole) of 4-cyanobenzoyl chloride in 100 ml of tetrahydrofuran was added dropwise at 0° C. The stirred reaction mixture was allowed to reach room temperature in the course of 45 minutes. It was poured onto water, and the precipitated solid was filtered off, washed with ethanol and dried to give 16.4 g of N-(4-cyanobenzoyl)-N'-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthoyl)-hydrazine of melting point 274°-277° C.

1. customno longer formed
2. customThereafter, the mixture was evaporated down
3. additiontoluene was added several times
4. customthe mixture was evaporated down again
5. customto remove residual thionyl chloride
6. dissolutionThe residue was dissolved in 75 ml of isopropanol
7. stirringthe mixture was stirred again vigorously
8. waitThe mixture was left
9. waitto stand overnight
10. filtrationafter which the solid was filtered off
11. extractionthe filtrate was extracted with water/ether
12. washThe organic phase was washed with water
13. dry with materialdried over sodium sulfate
14. customevaporated down
15. customThe stirred reaction mixture
16. customto reach room temperature in the course of 45 minutes
17. additionIt was poured onto water
18. filtrationthe precipitated solid was filtered off
19. washwashed with ethanol
20. customdried