3,4-dihydro-2H-pyran → HCID 18999424, compound

HRID 2260095Notes

Reaction equation

HRID 2260095 reaction equation
[C:1]1([C:7]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:8]([OH:10])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[O:23]1[CH:28]=[CH:27][CH2:26][CH2:25][CH2:24]1>Cl>[O:23]1[CH2:28][CH2:27][CH2:26][CH2:25][CH:24]1[O:9][C:8](=[O:10])[C:7]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)([C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1)[C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1

Participants

4

Reactant 2

HCID 80803,4-dihydro-2H-pyranHCID 68992Triphenylacetic acid

Product 1

HCID 18999424HCID 18999424, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidCatalyst

Conditions

Temperature
70 °C

Procedure

10 g (35 mmol) of triphenylacetic acid are mixed with 8.8 g (104 mmol) of 3,4-dihydro-2H-pyran and 2 drops of concentrated hydrochloric acid are added to the mixture. The solution is then stirred at 70° C. for 3 hours and working up is thereafter effected in accordance with the general procedure described in Example A. Recrystallisation from n-hexane gives a product which melts at 115° C.

Workup

  1. additionare added to the mixture
  2. customRecrystallisation from n-hexane
  3. customgives a product which melts at 115° C.

Sources & evidence

ORD record
ord-7025b296abe64c5c95c7c008a55cb3a9
Source dataset
uspto-grants-1995_12
Patent number
US05476751

Reaction notes

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