反应详情

In an oven dried nitrogen purged 3 neck 50 mL round bottom flask, 5.00 g (37.75 mmol) of 5-methoxybenzimidazole in 20 mL of dry dimethylformamide is reacted with 1.66 g (41.53 mmol) of sodium hydride at room temperature for 4 h. 2.58 mL (41.53 mmol) of iodomethane is added and reaction is allowed to stir at room temperature overnight. Reaction is quenched with water, layers are separated, extracted aqueous 3×50 mL ethyl acetate, dried (MgSO4), and concentrated. The crude mixture is purified by chromatography using dichloromethane: methanol as a solvent system. Product containing fractions are combined to obtain 3.50 g of the title compound which is used as is, 57% yield.

1. customreaction
2. customReaction
3. customis quenched with water, layers
4. customare separated
5. extractionextracted aqueous 3×50 mL ethyl acetate
6. dry with materialdried (MgSO4)
7. concentrationconcentrated
8. customThe crude mixture is purified by chromatography
9. additionProduct containing fractions