Phosphorus oxychloride → HCID 67377837, compound

HRID 2260505Notes

Reaction equation

HRID 2260505 reaction equation
O[N:2]1[C:7]2=[CH:8][N:9]=[N:10][C:6]2=[CH:5][N:4]=[CH:3]1.P(Cl)(Cl)([Cl:13])=O>>[Cl:13][N:2]1[C:7]2=[CH:8][N:9]=[N:10][C:6]2=[CH:5][N:4]=[CH:3]1

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 66654739HCID 66654739, compound

Product 1

HCID 67377837HCID 67377837, compound

Procedure

The compounds of Formula (5) that are pyrazolopyrimidines of the structure ##STR38## where E is CR1 and X is NH2, Scheme 12, can be synthesized from the corresponding 4-hydroxypyrazolopyrimidine of Formula (25) and phosphoryl chloride to give the corresponding 4-chloropyrazolopyrimidine of Formula (27) which is then treated with ammonia to give compounds of Formula (28). ##STR39##

Sources & evidence

ORD record
ord-64bd421b8d084dea9d055590f73206a9
Source dataset
uspto-grants-1995_12
Patent number
US05478830

Reaction notes

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