反应详情

温度

110 °C

Sodium azide (1.31 g) and ammonium chloride (1.07 g) were added to a solution of 4-amino-2-chloropyridine (2 g) in dimethylformamide (20 ml) and the mixture was stirred at 110° C. for 10 hours. After the insoluble material was filtered off, the filtrate was concentrated under reduced pressure. The residue obtained was purified by silica gel column chromatography to give 1.83 g of 4-amino-2-azidopyridine, melting point 220° C. (decomposition).

1. filtrationAfter the insoluble material was filtered off
2. concentrationthe filtrate was concentrated under reduced pressure
3. customThe residue obtained
4. customwas purified by silica gel column chromatography