反应详情

A mixture of 4-[2-(N-benzoyl-N-methylamino)ethoxy]benzaldehyde (3.94 g), 2,4-thiazolidinedione (1.79 g), benzoic acid (0.2 g) and piperidine (0.2 ml) were heated at reflux in toluene (250 ml) in a Dean and Stark apparatus. After 5 hours at reflux the mixture was allowed to cool and crystallise overnight. The title compound, mp 178-180° C., was filtered off, washed with cold toluene and dried under vacuum.

1. temperaturewere heated
2. temperatureAfter 5 hours at reflux the mixture
3. temperatureto cool
4. customcrystallise overnight
5. filtrationThe title compound, mp 178-180° C., was filtered off
6. washwashed with cold toluene
7. customdried under vacuum