反应详情

A mixture of 2,3-diamino-p-xylene (5.1 g), formic acid (88%, 200 mL) and 12N HCl (20 mL) is heated to reflux for 3 hours. The resulting mixture is cooled to room temperature and rotary evaporated. The residue is diluted with water (100 mL), then basified with ammonium hydroxide (28-30%). The suspension is extracted with ethyl acetate (3×100 mL). The combined extracts are dried over MgSO4 and rotary evaporated to afford 4,7-dimethylbenzimidazole as a yellow solid.

1. temperatureis heated
2. temperatureto reflux for 3 hours
3. extractionThe suspension is extracted with ethyl acetate (3×100 mL)
4. dry with materialThe combined extracts are dried over MgSO4
5. customrotary evaporated