反应详情

温度

210 °C

90 mg of 3-(3-Bromo-thieno[3,2-b]pyridin-2-yl)-8-(1-ethyl-propyl)-2,6-dimethyl-imidazo[1,2-b]pyridazine (0.21 mmol), 57 mg of CF3CO2Na (0.42 mmol) and 80 mg of CuI (0.42 mmol) are placed into microwave vessel with 3 ml of DMF/toluene=2/1. The vial is capped and heated at 210° C. for 60 min in microwave. The reaction mixture is applied onto silica-gel column (Hexane:AcOEt=8:1) directly to produce the tile compound. 27 mg (31%) mass spectrum (m/e): 419 (M+1); 1H-NMR (CDCl3): 8.88 (dd, 1H, J=4.9 Hz, 1.4 Hz), 8.22 (dd, 1H, J=7.8 Hz, 1.4 Hz), 7.4 (dd, 1H, J=7.8 Hz, 4.9 Hz), 6.74 (s, 1H), 3.31 (m, 1H), 2.53 (s, 3H), 2.79 (s, 3H), 1.85 (m, 4H), 0.88 (t, 6H, J=7.4 Hz).

1. customThe vial is capped
2. customto produce the tile compound