Ethyl 3-(5-formyl-1-benzofuran-3-yl)prop-2-enoate → HCID 57469675, compound

HRID 2261107Notes

Reaction equation

HRID 2261107 reaction equation
[CH2:1]([O:3][C:4](=[O:18])[CH:5]=[CH:6][C:7]1[C:11]2[CH:12]=[C:13]([CH:16]=[O:17])[CH:14]=[CH:15][C:10]=2[O:9][CH:8]=1)[CH3:2]>CCOC(C)=O.[Pd]>[CH2:1]([O:3][C:4](=[O:18])[CH2:5][CH2:6][C:7]1[C:11]2[CH:12]=[C:13]([CH:16]=[O:17])[CH:14]=[CH:15][C:10]=2[O:9][CH:8]=1)[CH3:2]

Participants

4

Reactant 1

HCID 71378267Ethyl 3-(5-formyl-1-benzofuran-3-yl)prop-2-enoate2×

Product 1

HCID 57469675HCID 57469675, compoundYield 80%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

100 mg of 3-(5-Formyl-benzofuran-3-yl)-acrylic acid ethyl ester (intermediate 62) were dissolved in EtOAc in the presence of Palladium on charcoal and Argon. To this was connected a H2-balloon and hydrogenation was carried out for 12 h. The palladium was filtered off and the solvents were evaporated affording pure title compound (80 mg, 80%).

Workup

  1. filtrationThe palladium was filtered off
  2. customthe solvents were evaporated

Sources & evidence

ORD record
ord-7e535af8e49a47aa9fb79c8ee8bc9863
Source dataset
uspto-grants-2010_12
Patent number
US07846925B2

Reaction notes

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