反应详情

Methyl 4-(3-methyl-1,2,4-oxadiazol-5-yl)benzoate (J. R. Young and R. J. DeVita, Tetrahedron Lett., 1998, 39, 3931) was dissolved in a mixture of dioxan (110 ml), water (70 ml) and isopropanol (30 ml), and lithium hydroxide (1.38 g) was added. The mixture was stirred at room temperature for ca 5 h and then the mixture was acidified to ca pH 4 by addition of Amberlyst 15 H+ resin. The resin was removed by filtration and the filtrate was concentrated in vacuo. The solid white precipitate which was obtained was collected by filtration, washed with water on the filter and dried in vacuo at 40° C. for 48 h to give the title compound (D18) (4.23 g).

1. additionwas added
2. additionby addition of Amberlyst 15 H+ resin
3. customThe resin was removed by filtration
4. concentrationthe filtrate was concentrated in vacuo
5. customThe solid white precipitate which was obtained
6. filtrationwas collected by filtration
7. washwashed with water on the
8. filtrationfilter
9. customdried in vacuo at 40° C. for 48 h