反应详情

0.20 g of propargyl alcohol was dissolved in 20 ml of tetrahydrofuran, and 0.13 g of 60% sodium hydride was added at room temperature. The mixture was stirred at room temperature for 1 hour. After 0.50 g of ethyl 2-chloro-1,3-thiazole-4-carboxylate was added, the reaction mixture was stirred at room temperature for 3 hours. After aqueous saturated ammonium chloride was added, the reaction mixture was extracted with methyl-t-butyl ether. The organic layer was washed with aqueous saturated sodium chloride, dried over anhydrous sodium sulfate and then concentrated under reduced pressure. The residue was subjected to silica gel column chromatography to obtain 0.33 g of ethyl 2-(2-propynyloxy)-1,3-thiazole-4-carboxylate.

1. stirringthe reaction mixture was stirred at room temperature for 3 hours
2. extractionthe reaction mixture was extracted with methyl-t-butyl ether
3. washThe organic layer was washed with aqueous saturated sodium chloride
4. dry with materialdried over anhydrous sodium sulfate
5. concentrationconcentrated under reduced pressure