Carbon tetrabromide → HCID 57736292, compound

HRID 2261326Notes

Reaction equation

HRID 2261326 reaction equation
[F:1][C:2]([F:12])([F:11])[C:3]1[O:7][N:6]=[C:5]([CH:8](O)[CH3:9])[CH:4]=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C(Br)(Br)(Br)[Br:33]>C(OCC)C>[Br:33][CH:8]([C:5]1[CH:4]=[C:3]([C:2]([F:12])([F:11])[F:1])[O:7][N:6]=1)[CH3:9]

Participants

5

Reactant 3

HCID 11205Carbon tetrabromideHCID 11776TriphenylphosphineHCID 57736325α-Methyl-5-(trifluoromethyl)-3-isoxazolemethanol

Product 1

HCID 57736292HCID 57736292, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

1-(5-Trifluoromethyl-isoxazol-3-yl)ethanol was dissolved in 35 ml of diethyl ether, and 2.93 g of triphenylphosphine and 3.71 g of carbon tetrabromide were then added. The mixture was stirred at room temperature for 1 hour. The reaction mixture was subjected to silica gel column chromatography to obtain 1.14 g of 3-(1-bromoethyl)-5-trifluoromethylisoxazole.

Sources & evidence

ORD record
ord-2768f0ddf8164d5f920c87efd610098f
Source dataset
uspto-grants-2010_12
Patent number
US07846956B2

Reaction notes

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