Carbon tetrabromide → HCID 57736348, compound

HRID 2261328Notes

Reaction equation

HRID 2261328 reaction equation
[F:1][C:2]([F:13])([F:12])[C:3]1[O:7][N:6]=[C:5]([CH:8](O)[CH2:9][CH3:10])[CH:4]=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C(Br)(Br)(Br)[Br:34]>C(OCC)C>[Br:34][CH:8]([C:5]1[CH:4]=[C:3]([C:2]([F:13])([F:12])[F:1])[O:7][N:6]=1)[CH2:9][CH3:10]

Participants

5

Reactant 3

HCID 11205Carbon tetrabromideHCID 11776TriphenylphosphineHCID 57736276HCID 57736276, compound

Product 1

HCID 57736348HCID 57736348, compoundYield 46.4%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

1.63 g of 1-(5-trifluoromethyl-isoxazol-3-yl)propanol was dissolved in 45 ml of diethyl ether, and 4.20 g of triphenylphosphine and 5.31 g of carbon tetrabromide were then added. The mixture was stirred at room temperature for 1 hour. The reaction mixture was subjected to silica gel column chromatography to obtain 1.00 g of 3-(1-bromopropyl)-5-trifluoromethylisoxazole.

Sources & evidence

ORD record
ord-75599e30161c4f58948d074c4da0ef2d
Source dataset
uspto-grants-2010_12
Patent number
US07846956B2

Reaction notes

Loading…