1,2-Dichloroethane → HCID 11406298, compound

HRID 2261395Notes

Reaction equation

HRID 2261395 reaction equation
[CH2:1]([O:8][NH2:9])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:10]([N:17]1[CH2:22][CH2:21][CH:20]=[C:19]([CH2:23][CH2:24][C:25]([OH:27])=O)[C:18]1=[O:28])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.[CH2:29](Cl)CCl>>[CH2:1]([O:8][NH:9][C:25](=[O:27])[CH2:24][CH2:23][C:19]1[C:18](=[O:28])[N:17]([CH2:10][CH2:11][C:16]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:29]=2)[CH2:22][CH2:21][CH:20]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 111,2-DichloroethaneHCID 102313O-BenzylhydroxylamineHCID 11219135HCID 11219135, compound

Product 1

HCID 11406298HCID 11406298, compoundYield 75%

Procedure

Benzyloxyamine was added to organic solvent dissolving 30 mg of 3-(1-benzyl-2-oxo-1,2,5,6-tetrahydro-pyridin-3-yl)-propionic acid (0.15 mmol) prepared by above Example 12 in EDC. The resulting compound was purified by Silica gel column chromatography with ethylacetate/chloroform (1:1) solvent mixture as an eluant to give 41 mg of the title compound (g5) (yield: 75%).

Workup

  1. customThe resulting compound was purified by Silica gel column chromatography with ethylacetate/chloroform (1:1) solvent mixture as an eluant

Sources & evidence

ORD record
ord-cfea9ceb45f64acbaad18646f7e94af7
Source dataset
uspto-grants-2010_12
Patent number
US07846963B2

Reaction notes

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