2,2,2-Trifluoroethanol → HCID 15578587, compound

Temperature

0 °C

2,2,2-Trifluoroethanol (15 ml, 0.15 mol) and triethylamine (4.5 ml, 32.12 mmol) were added to 30 ml of dichloromethane, and cooled to 0° C. After 10 min, 2.94 ml of 3-bromopropionyl chloride (29.2 mmol) was added dropwise thereto. The mixture was warmed to room temperature and stirred for 5 hrs. After the reaction was terminated by addition of water, the mixture was extracted with ethyl acetate, and the solvent was evaporated under a reduced pressure. The solid impurities were removed by filtration to obtain the title compound as a liquid (3.53 g).

1. temperatureThe mixture was warmed to room temperature
2. customAfter the reaction was terminated by addition of water
3. extractionthe mixture was extracted with ethyl acetate
4. customthe solvent was evaporated under a reduced pressure
5. customThe solid impurities were removed by filtration

ORD record

ord-f97b34554bfa4b21b1eb2ca8828a7475

Source dataset

uspto-grants-2010_12

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07846975B2