反应详情

温度

80 °C

A solution of 4-bromo-3-methyl-phenol (135 mg, 0.723 mmol) and 5-bromomethyl-1-(2,6-dichloro-phenyl)-4-isopropyl-1H-pyrazole (210 mg, 0.603 mmol) in dimethylformamide (1.0 mL) is treated with potassium carbonate (84 mg, 0.603 mmol). The reaction mixture is heated at 80° C. for 60 minutes and cooled to room temperature. The mixture is loaded directly onto a silica gel column and purified with 25% EtOAc/Hexanes to provide 5-(4-bromo-3-methyl-phenoxymethyl)-1-(2,6-dichloro-phenyl)-4-isopropyl-1H-pyrazole (0.258 g, 94%). ES/MS m/e (M+1) 454.8.

1. temperaturecooled to room temperature
2. custompurified with 25% EtOAc/Hexanes