2-Methoxyethylamine → N-(2-methoxyethyl)methanesulfonamide

HRID 2262140Notes

Reaction equation

HRID 2262140 reaction equation
[CH3:1][O:2][CH2:3][CH2:4][NH2:5].C(N(CC)CC)C.[CH3:13][S:14](Cl)(=[O:16])=[O:15]>ClCCl>[CH3:1][O:2][CH2:3][CH2:4][NH:5][S:14]([CH3:13])(=[O:16])=[O:15]

Participants

5

Reactant 3

HCID 80182-MethoxyethylamineHCID 8471TriethylamineHCID 31297Methanesulfonyl chloride

Product 1

HCID 3522477N-(2-methoxyethyl)methanesulfonamide

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a stirring solution of 2-methoxyethylamine (0.58 ml) in dichloromethane (10 ml) was added triethylamine (1.0 ml) and methanesulphonyl chloride (0.51 ml). The mixture was stirred at room temperature overnight. The solvents were removed in vacuo to give a crude product which was purified by flash chromatography to give N-(2-Methoxy-ethyl)-methanesulfonamide (0.74 g).

Workup

  1. customThe solvents were removed in vacuo
  2. customto give a crude product which
  3. customwas purified by flash chromatography

Sources & evidence

ORD record
ord-5b200236af3d450eb70b4c98fe8450f0
Source dataset
uspto-grants-2010_12
Patent number
US07846929B2

Reaction notes

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