Carbonochloridic acid, 3-chloropropyl ester → HCID 86612596, compound

HRID 2262465Notes

Reaction equation

HRID 2262465 reaction equation
[O:1]1[CH2:5][CH2:4][CH2:3][CH:2]1[C:6]([N:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1)=[O:7].Cl[C:15]([O:17][CH2:18][CH2:19][CH2:20][Cl:21])=[O:16].C(N(CC)C(C)C)(C)C>ClCCl>[Cl:21][CH2:20][CH2:19][CH2:18][O:17][C:15]([N:11]1[CH2:10][CH2:9][N:8]([C:6]([CH:2]2[CH2:3][CH2:4][CH2:5][O:1]2)=[O:7])[CH2:13][CH2:12]1)=[O:16]

Participants

5

Reactant 3

HCID 69399Carbonochloridic acid, 3-chloropropyl esterHCID 81531DiisopropylethylamineHCID 27346411-(Tetrahydro-2-furoyl)piperazine

Product 1

HCID 86612596HCID 86612596, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a 0° C. solution of 1-(tetrahydrofuran-2-ylcarbonyl)piperazine (202 mg, 1.1 mmol) in dichloromethane (5 mL) was added 3-chloropropyl chloroformate (133 μL, 1.1 mmol) followed by N,N-diisopropylethylamine (192 μL, 1.1 mmol). The reaction was allowed to reach room temperature over 2 h, at which time the reaction was evaporated to yield the title compound as a wheat colored oil that was used without further purification.

Workup

  1. customthe reaction was evaporated

Sources & evidence

ORD record
ord-1dea4ccbf0c646fba55dcfba630d4091
Source dataset
uspto-grants-2010_12
Patent number
US07851467B2

Reaction notes

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