Ammonium Hydroxide → HCID 68685144, compound

HRID 2262665Notes

Reaction equation

C([O:3][C:4](=O)[CH2:5][C:6]1[CH:11]=[C:10]([N:12]2[CH2:17][CH2:16][N:15]([CH3:18])[CH2:14][CH2:13]2)[CH:9]=[CH:8][C:7]=1[NH:19][C:20](=[O:22])[CH3:21])C.[NH4+:24].[OH-]>>[C:20]([NH:19][C:7]1[CH:8]=[CH:9][C:10]([N:12]2[CH2:17][CH2:16][N:15]([CH3:18])[CH2:14][CH2:13]2)=[CH:11][C:6]=1[CH2:5][C:4]([NH2:24])=[O:3])(=[O:22])[CH3:21]

Participants

Reactant 2

HCID 14923Ammonium Hydroxide

HCID 68684870HCID 68684870, compound

Product 1

HCID 68685144HCID 68685144, compound

Procedure

[2-Acetylamino-5-(4-methyl-piperazin-1-yl)-phenyl]-acetic acid ethyl ester (450 mg, 1.41 mmol) is suspended in a 33% aqueous NH4OH solution (200 mL), and stirred for 16 h at RT. The volume is carefully reduced under vacuum until the title compound remains as a brown solid, which is further dried under high vacuum. ES+-MS: 291 [M+H]+.

Sources & evidence

ORD record: ord-7ab6aba2125547d39ea2b832b6516cda
Source dataset: uspto-grants-2010_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07851475B2

Reaction notes

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