Oxalyl chloride → 2,2-diphenylpropanoyl Chloride

HRID 2262672Notes

Reaction equation

HRID 2262672 reaction equation
C(Cl)(=O)C([Cl:4])=O.[C:7]1([C:13]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)([CH3:17])[C:14](O)=[O:15])[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1>CN(C)C=O.ClCCl>[C:7]1([C:13]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)([CH3:17])[C:14]([Cl:4])=[O:15])[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

Participants

5

Reactant 2

HCID 65578Oxalyl chlorideHCID 796762,2-Diphenylpropionic acid

Product 1

HCID 114479422,2-diphenylpropanoyl Chloride

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideCatalystHCID 6344DichloromethaneSolvent

Conditions

Temperature
50 °C

Procedure

52.08 g (0.33 mol) of oxalyl chloride are slowly added dropwise at 20° C. to a suspension of 25.0 g (0.11 mol) of 2,2-diphenylpropionic acid, 100 mL of dichloromethane, and 4 drops of dimethylformamide. The mixture is stirred for 1 hour at 20° C. and 0.5 hour at 50° C. The solvent is distilled off and the residue remaining is used in the next step without any further purification.

Workup

  1. distillationThe solvent is distilled off
  2. customthe residue remaining is used in the next step without any further purification

Sources & evidence

ORD record
ord-fa695cefe1bc4db3ab6860ab23de44c0
Source dataset
uspto-grants-2010_12
Patent number
US07851483B2

Reaction notes

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