反应详情

To a solution of 5-chloro-3-phenyl-1,2,4-oxadiazole (99.9 mg, 0.555 mmol) and N-1,2-benzisoxazol-3-ylpiperazine-1-carboxamide trifluoroacetate (200 mg, 0.555 mmol) in N,N-dimethylformamide (2 ml) was added triethylamine (0.389 ml, 2.78 mmol) at room temperature, and the mixture was stirred at room temperature for 5 minutes. The reaction mixture was poured to water, and the desired product as a solid was separated by filtration. The resulting solid was recrystallized from a mixed solvent of ethyl acetate and tetrahydrofuran to give 157 mg (72.4%) of the desired product. mp 215-216° C.

1. customthe desired product as a solid was separated by filtration
2. customThe resulting solid was recrystallized from a mixed solvent of ethyl acetate and tetrahydrofuran