Hydrochloric Acid → 1-(4-Phenyl-1,3-thiazol-2-yl)piperazine

tert-Butyl 4-(4-phenyl-1,3-thiazol-2-yl)piperazine-1-carboxylate (691 mg, 2.00 mmol) was dissolved in ethyl acetate (50 ml), and a solution of 4 N hydrogen chloride in ethyl acetate (11 ml) was added thereto, followed by stirring at room temperature for 1 hour and half. Diethyl ether (20 ml) was poured to the reaction mixture, and a solid was separated by filtration, which was dissolved in an aqueous 1 N sodium hydroxide solution (7 ml). Water was poured to the reaction mixture, and the resulting solution was extracted with chloroform. The extract was washed with water and dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure to give 396 mg (80.8%) of the desired product as an oil.

1. customa solid was separated by filtration, which
2. dissolutionwas dissolved in an aqueous 1 N sodium hydroxide solution (7 ml)
3. additionWater was poured to the reaction mixture
4. extractionthe resulting solution was extracted with chloroform
5. washThe extract was washed with water
6. dry with materialdried over anhydrous magnesium sulfate
7. distillationThe solvent was distilled off under reduced pressure

ORD record

ord-7589fb7cb62749a891620c5bbd18c510

Source dataset

uspto-grants-2010_12

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07851473B2