反应详情

To a solution of tert-butyl 4-[3-(3-thienyl)-1,2,4-thiadiazol-5-yl]piperazine-1-carboxylate (3.70 g, 10.5 mmol) in ethyl acetate (60 ml) was added a solution of 4 N hydrochloric acid in ethyl acetate (30 ml), and the mixture was stirred at room temperature for 22 hours. Hexane (200 ml) was poured to the reaction mixture, and a solid was separated by filtration. The obtained solid was dissolved in an aqueous saturated sodium hydrogen carbonate solution, followed by stirring at room temperature for 2 hours. Water was poured to the reaction mixture, and 1.86 g (70.4%) of the desired product as a solid was separated by filtration.

1. customa solid was separated by filtration
2. dissolutionThe obtained solid was dissolved in an aqueous saturated sodium hydrogen carbonate solution
3. stirringby stirring at room temperature for 2 hours
4. additionWater was poured to the reaction mixture, and 1.86 g (70.4%) of the desired product as a solid
5. customwas separated by filtration