反应详情

温度

70 °C

A mixture of 2,2,2-trichloroethyl imidazo[1,2-b]pyridazin-6-ylcarbamate (198 mg, 0.408 mmol), 1-(4-phenyl-1,3-thiazol-2-yl)piperazine (200 mg, 0.815 mmol) and diisopropylethylamine (0.076 ml, 0.408 mmol) in dimethylsulfoxide (2.7 ml) was stirred at 70° C. for 15 hours. Water was poured into the reaction solution, and the mixture was exacted with ethyl acetate. The extract was washed with water and dried over anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure. The residue was recrystallized from a mixed solvent of hexane and tetrahydrofuran to give 110 mg (66.5%) of the desired product as a solid.

1. washThe extract was washed with water
2. dry with materialdried over anhydrous magnesium sulfate
3. distillationthe solvent was distilled off under reduced pressure
4. customThe residue was recrystallized from a mixed solvent of hexane and tetrahydrofuran