Hydrochloric Acid → HCID 68777896, compound

HRID 2263212Notes

Reaction equation

HRID 2263212 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]=[C:10](C3CCN(C(OC(C)(C)C)=O)CC3)[S:11][CH:12]=2)=[CH:4][CH:3]=1.[ClH:26].C(O[CH2:31][CH3:32])(=O)C>>[ClH:26].[ClH:26].[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[N:9]=[C:10]([N:9]3[CH2:32][CH2:31][CH2:4][CH2:5][CH2:8]3)[S:11][CH:12]=2)=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 8857Ethyl Acetate2×HCID 68778420HCID 68778420, compound

Product 1

HCID 68777896HCID 68777896, compoundYield 82%

Procedure

To a solution of tert-butyl 4-[4-(4-fluorophenyl)-1,3-thiazol-2-yl]piperidine-1-carboxylate (2.49 g, 6.85 mmol) in ethyl acetate (100 ml) was added a 4N solution (100 ml) of hydrogen chloride in ethyl acetate, and the mixture was stirred at room temperature for 12 hours. The solvent was distilled off under reduced pressure to give 1.88 g (82.0%) of the desired product as a solid.

Workup

  1. distillationThe solvent was distilled off under reduced pressure

Sources & evidence

ORD record
ord-717603962f40470fbecfa28995373bfc
Source dataset
uspto-grants-2010_12
Patent number
US07851473B2

Reaction notes

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