Water → 2,4-Difluorophenacyl thiocyanate

HRID 2263250Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2263250
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([F:11])=[CH:7][C:6]=1[F:12])=[O:4].[S-:13][C:14]#[N:15].[K+].O>C(O)C>[F:12][C:6]1[CH:7]=[C:8]([F:11])[CH:9]=[CH:10][C:5]=1[C:3](=[O:4])[CH2:2][S:13][C:14]#[N:15]

Komponenten

5

Edukt 3

HCID 962WaterHCID 516872Potassium thiocyanateHCID 27741852-Bromo-2',4'-difluoroacetophenone

Produkt 1

HCID 450368272,4-Difluorophenacyl thiocyanateAusbeute 74,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A solution of 2-bromo-1-(2,4-difluorophenyl)ethanone (5.0 g, 21.3 mmol) and potassium thiocyanate (2.07 g, 21.3 mmol) in ethanol (50 ml) was stirred at 80° C. for 2 hours. After cooling to room temperature, water (70 ml) was poured to the reaction mixture. A crystal was collected by filtration and washed with 50% aqueous ethanol to give 3.39 g (74.7%) of the desired product as a solid.

Aufarbeitung

  1. filtrationA crystal was collected by filtration
  2. washwashed with 50% aqueous ethanol

Quellen und Nachweise

ORD-Eintrag
ord-febcf29f71a34e8982302bf58067957e
Quelldatensatz
uspto-grants-2010_12
Patentnummer
US07851473B2

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