反应详情

A 4 N solution (25 ml) of hydrogen chloride in ethyl acetate was added to a solution of tert-butyl 4-[4-(3-cyanophenyl)-1,3-thiazol-2-yl]piperazine-1-carboxylate (920 mg, 2.48 mmol) in ethyl acetate (50 ml), the mixture was stirred at room temperature for 6 hours, and the solvent was distilled off under reduced pressure. The residue was dissolved in water, neutralized with a 1 N sodium hydroxide aqueous solution, and extracted with chloroform. The extract was washed with water, and dried over anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure to give 438 mg (65.2%) of the desired product as a solid.

1. distillationthe solvent was distilled off under reduced pressure
2. dissolutionThe residue was dissolved in water
3. extractionextracted with chloroform
4. washThe extract was washed with water
5. dry with materialdried over anhydrous magnesium sulfate
6. distillationthe solvent was distilled off under reduced pressure