Hydrochloric Acid → HCID 61781038, compound

HRID 2263316Notes

Reaction equation

HRID 2263316 reaction equation
Cl.[Cl:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[N:10]=[C:11]([N:14]2[CH2:19][CH2:18][N:17](C(OC(C)(C)C)=O)[CH2:16][CH2:15]2)[S:12][CH:13]=1>C(OCC)(=O)C>[Cl:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[N:10]=[C:11]([N:14]2[CH2:15][CH2:16][NH:17][CH2:18][CH2:19]2)[S:12][CH:13]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 68781134HCID 68781134, compound

Product 1

HCID 61781038HCID 61781038, compoundYield 67.9%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

A 4 N solution (100 ml) of hydrogen chloride in ethyl acetate was added to a solution of tert-butyl 4-[4-(2-chlorophenyl)-1,3-thiazol-2-yl]piperazine-1-carboxylate (4.15 g, 10.9 mmol) in ethyl acetate (100 ml), the mixture was stirred at room temperature for 5 hours, and the solvent was distilled off under reduced pressure. The residue was dissolved in water, neutralized with a 1 N sodium hydroxide aqueous solution, and extracted with chloroform. The extract was washed with water, and dried over anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure to give 2.07 g (67.6%) of the desired product as a solid.

Workup

  1. distillationthe solvent was distilled off under reduced pressure
  2. dissolutionThe residue was dissolved in water
  3. extractionextracted with chloroform
  4. washThe extract was washed with water
  5. dry with materialdried over anhydrous magnesium sulfate
  6. distillationthe solvent was distilled off under reduced pressure

Sources & evidence

ORD record
ord-40387df07c5747039b7ea04345798b06
Source dataset
uspto-grants-2010_12
Patent number
US07851473B2

Reaction notes

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