Hydrochloric Acid → HCID 11536246, compound

HRID 2263497Notes

Reaction equation

HRID 2263497 reaction equation
[F:1][C:2]1[C:7]([C:8]([F:11])([F:10])[F:9])=[CH:6][CH:5]=[CH:4][C:3]=1[C:12]1[CH2:13][CH2:14][N:15]([CH3:18])[CH2:16][CH:17]=1.Cl>[Pd].CO>[F:1][C:2]1[C:7]([C:8]([F:9])([F:10])[F:11])=[CH:6][CH:5]=[CH:4][C:3]=1[CH:12]1[CH2:17][CH2:16][N:15]([CH3:18])[CH2:14][CH2:13]1

Participants

5

Reactant 2

HCID 313Hydrochloric Acid2×HCID 57438801HCID 57438801, compound

Product 1

HCID 11536246HCID 11536246, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

Preparation according to Example 2: 4-[2-fluoro-3-(trifluoromethyl)phenyl]-1-methyl-1,2,3,6-tetrahydropyridine (0.59 g, 2.28 mmol), methanol (30 ml), palladium on carbon (0.07 g) and hydrochloric acid (0.1 ml, conc). Yield: 0.43 g. The amine was converted to the hydrochloric acid salt and recrystallized from ethanol/diethyl ether: M.p. 260-261° C. MS m/z (relative intensity, 70 eV) 261 (M+, 69), 260 (bp), 242 (9), 97 (12) 70 (37).

Workup

  1. customPreparation
  2. customrecrystallized from ethanol/diethyl ether

Sources & evidence

ORD record
ord-b208b4246ace486f9459c90858614e75
Source dataset
uspto-grants-2010_12
Patent number
US07851629B2

Reaction notes

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