Hydrochloric Acid → N-(2-oxo-2-phenylethyl)methanesulfonamide

Temperature

0 °C

2-Aminoacetophenone hydrochloride (6.10 g, 35.5 mmol) was dissolved in dichloromethane (60 mL), and to the solution was added triethylamine (7.56 g, 74.9 mmol). The solution was cooled to 0° C., and to the solution was added methanesulfonyl chloride (2.84 mL, 36.5 mmol). The solution was stirred at the same temperature for 5 minutes, and then at room temperature for 2 hours. To the reaction mixture was added water and 1 mol/L hydrochloric acid, and the mixture was extracted with chloroform. The organic layer was dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure. The residue was suspended in chloroform (5 mL) and the suspension was stirred, and then, the resulted crystals were collected by filtration to give 2-(methylsulfonylamino)acetophenone (4.58 g, 57%).

1. waitat room temperature for 2 hours
2. extractionthe mixture was extracted with chloroform
3. dry with materialThe organic layer was dried over anhydrous sodium sulfate
4. customthe solvent was evaporated under reduced pressure
5. stirringthe suspension was stirred
6. filtrationthe resulted crystals were collected by filtration

ORD record

ord-60a35ed6a3da48d6865869d221442c22

Source dataset

uspto-grants-2010_12

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07851635B2