Triethylamine → HCID 86624406, compound

HRID 2264216Notes

Reaction equation

HRID 2264216 reaction equation
[F:1][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][C:7]=1[C:8]1[C:9]([C:16]2[CH:17]=[N:18][CH:19]=[CH:20][CH:21]=2)=[N:10][C:11]([NH2:15])=[C:12]([NH2:14])[CH:13]=1.[C:22](N1C=CN=C1)(N1C=CN=C1)=[S:23].C(N(CC)CC)C>C1COCC1>[F:1][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][C:7]=1[C:8]1[CH:13]=[C:12]2[NH:14][C:22](=[S:23])[NH:15][C:11]2=[N:10][C:9]=1[C:16]1[CH:17]=[N:18][CH:19]=[CH:20][CH:21]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 802641,1'-ThiocarbonyldiimidazoleHCID 595959543''-Fluoro-3,2':3',4''-terpyridine-5',6'-diamine2×

Product 1

HCID 86624406HCID 86624406, compoundYield 88.3%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of 3″-fluoro-3,2′:3′,4″-terpyridine-5′,6′-diamine (Intermediate 1, 2 g, 7.11 mmol), 1,1′-thiocarbonyldiimidazole (2.54 g, 14.22 mmol) and triethylamine (2 mL, 14.22 mmol) in THF (30 mL) was heated at 80° C. in a sealed tube. After 6 hours, the mixture was cooled and the solid was filtered, washed with NH4Cl aq. and water and dried to give the title compound (2.03 g, 88%) as a white solid.

Workup

  1. temperaturethe mixture was cooled
  2. filtrationthe solid was filtered
  3. washwashed with NH4Cl aq. and water
  4. customdried

Sources & evidence

ORD record
ord-54b4d8ab842b490cbc9b47bb93ca09ef
Source dataset
uspto-grants-2010_12
Patent number
US07855202B2

Reaction notes

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