Tetrahydrofuran → HCID 16117868, compound

HRID 2264229Notes

Reaction equation

HRID 2264229 reaction equation
[F:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([F:22])[C:7]=1[C:8]1[C:9]([C:16]2[CH:17]=[N:18][CH:19]=[CH:20][CH:21]=2)=[N:10][C:11]([NH2:15])=[C:12]([NH2:14])[CH:13]=1.C(N(CC)CC)C.C1C[O:33][CH2:32]C1>>[F:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([F:22])[C:7]=1[C:8]1[CH:13]=[C:12]2[NH:14][C:32](=[O:33])[NH:15][C:11]2=[N:10][C:9]=1[C:16]1[CH:17]=[N:18][CH:19]=[CH:20][CH:21]=1

Participants

4

Reactant 3

HCID 8028TetrahydrofuranHCID 8471TriethylamineHCID 595959713'',5''-Difluoro-3,2':3',4''-terpyridine-5',6'-diamine2×

Product 1

HCID 16117868HCID 16117868, compoundYield 59%

Procedure

A solution of 3″,5″-difluoro-3,2′:3′,4″-terpyridine-5′,6′-diamine (Intermediate 14, 0.045 g, 0.15 mmol), N,N′-carbonyldiimidazole (0.1 g, 0.6 mmol) and triethylamine (0.084 mL, 0.6 mmol) in THF (1.5 mL) was heated at 80° C. in a sealed tube. After 72 hours, the mixture was cooled and the solid was separated, washed with THF and dried to give the title compound (0.029 g, 59% of yield).

Workup

  1. temperaturethe mixture was cooled
  2. customthe solid was separated
  3. washwashed with THF
  4. customdried

Sources & evidence

ORD record
ord-fa06d19ee1424f0da58c16b7cd068bf9
Source dataset
uspto-grants-2010_12
Patent number
US07855202B2

Reaction notes

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