4-Aminotetrahydropyran → HCID 56663232, compound

HRID 2264266Notes

Reaction equation

HRID 2264266 reaction equation
[O:1]1[CH2:6][CH2:5][CH:4]([NH2:7])[CH2:3][CH2:2]1.C1(S([N:17]2[C:21]3=[N:22][CH:23]=[CH:24][CH:25]=[C:20]3[C:19]([C:26]3[CH:31]=[CH:30][N:29]=[C:28](Cl)[N:27]=3)=[CH:18]2)(=O)=O)C=CC=CC=1>>[O:1]1[CH2:6][CH2:5][CH:4]([NH:7][C:28]2[N:27]=[C:26]([C:19]3[C:20]4[C:21](=[N:22][CH:23]=[CH:24][CH:25]=4)[NH:17][CH:18]=3)[CH:31]=[CH:30][N:29]=2)[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 4192234-AminotetrahydropyranHCID 59596028HCID 59596028, compound

Product 1

HCID 56663232HCID 56663232, compoundYield 83.7%

Procedure

Using the procedure of example 1, tetrahydropyran-4-ylamine (0.8 g) was reacted with compound 1f (1.8 g) to provide compound 60 (1.2 g, 42%). 1H NMR (400 MHz, DMSO) δ 12.20 (s, 1H), 8.95 (s, 1H), 8.39 (s, 1H), 8.30 (d, 1H), 8.15 (d, 1H), 7.20 (m, 1 H), 7.06 (d, 1H), 7.04 (d, 1H), 4.00 (m, 1H), 3.90 (m, 2H), 3.45 (m, 2H), 1.90 (m, 2 H), 1.55 (m, 2H).

Sources & evidence

ORD record
ord-26a2ae6124b84336b070bbb7904ed106
Source dataset
uspto-grants-2010_12
Patent number
US07855205B2

Reaction notes

Loading…