Tetrahydro-4H-pyran-4-one → HCID 23112224, compound

HRID 2264327Notes

Reaction equation

HRID 2264327 reaction equation
[CH2:1]([NH:3][CH2:4][C:5]1[CH:10]=[C:9]([C:11]([O:13][CH2:14][CH3:15])=[O:12])[CH:8]=[CH:7][C:6]=1[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)[CH3:2].[O:22]1[CH2:27][CH2:26][C:25](=O)[CH2:24][CH2:23]1.C(O[BH-](OC(=O)C)OC(=O)C)(=O)C.[Na+]>C(O)(=O)C>[CH2:1]([N:3]([CH2:4][C:5]1[CH:10]=[C:9]([C:11]([O:13][CH2:14][CH3:15])=[O:12])[CH:8]=[CH:7][C:6]=1[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)[CH:25]1[CH2:26][CH2:27][O:22][CH2:23][CH2:24]1)[CH3:2]

Participants

5

Reactant 3

HCID 121599Tetrahydro-4H-pyran-4-oneHCID 5049666Sodium triacetoxyborohydrideHCID 23112226HCID 23112226, compound

Product 1

HCID 23112224HCID 23112224, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Ethyl 2-[(ethylamino)methyl]biphenyl-4-carboxylate and tetrahydro-4H-pyran-4-one were treated with sodium triacetoxyborohydride in the presence of acetic acid to obtain ethyl 2-{[ethyl(tetrahydro-2H-pyran-4-yl)amino]methyl}biphenyl-4-carboxylate.

Sources & evidence

ORD record
ord-865f9637eb1141b3b3a8836540a6be21
Source dataset
uspto-grants-2010_12
Patent number
US07855198B2

Reaction notes

Loading…