Chlorosuccinimide → HCID 23112210, compound

HRID 2264342Notes

Reaction equation

HRID 2264342 reaction equation
[F:1][C:2]([F:18])([F:17])[C:3]([NH:5][C:6]1[CH:7]=[CH:8][C:9]2[O:14][CH2:13][C:12](=[O:15])[NH:11][C:10]=2[CH:16]=1)=[O:4].[Cl:19]N1C(=O)CCC1=O>CN(C=O)C>[Cl:19][C:8]1[C:9]2[O:14][CH2:13][C:12](=[O:15])[NH:11][C:10]=2[CH:16]=[C:6]([NH:5][C:3](=[O:4])[C:2]([F:1])([F:17])[F:18])[CH:7]=1

Participants

4

Reactant 2

HCID 31398ChlorosuccinimideHCID 24307809HCID 24307809, compound

Product 1

HCID 23112210HCID 23112210, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

2,2,2-Trifluoro-N-(3-oxo-3,4-dihydro-2H-1,4-benzoxazin-6-yl)acetamide was treated with N-chlorosuccinimide in DMF to obtain N-(8-chloro-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-6-yl)-2,2,2-trifluoroacetamide.

Sources & evidence

ORD record
ord-9d9dff7e3557422a93591310ae7e5e3e
Source dataset
uspto-grants-2010_12
Patent number
US07855198B2

Reaction notes

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