Triethylamine → HCID 178478386, compound

HRID 2264381Notes

Reaction equation

HRID 2264381 reaction equation
[Cl:1][C:2]1[N:11]=[C:10](Cl)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[NH2:13][C:14]1[CH:18]=[C:17]([CH:19]2[CH2:23][CH2:22][CH2:21][CH2:20]2)[NH:16][N:15]=1.C(N(CC)CC)C>C(O)C>[Cl:1][C:2]1[N:11]=[C:10]([NH:13][C:14]2[NH:15][N:16]=[C:17]([CH:19]3[CH2:23][CH2:22][CH2:21][CH2:20]3)[CH:18]=2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 2528862,4-DichloroquinazolineHCID 221768275-Cyclopentyl-1H-pyrazol-3-amine

Product 1

HCID 178478386HCID 178478386, compoundYield 66.1%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2,4-Dichloroquinazoline (0.657 g, 3.3 mmol) in ethanol (9 ml) was treated with 3-amino-5-cyclopentyl pyrazole (0.5 g, 3.3 mmol) and triethylamine (0.46 ml, 3.3 mmol) and stirred overnight at room temperature. The mixture was filtered and the solid washed with ethanol to give (2-chloro-quinazolin-4-yl)-(5-cyclopentyl-2H-pyrazol-3-yl)-amine as colourless crystals (684 mg, 66%).

Workup

  1. filtrationThe mixture was filtered
  2. washthe solid washed with ethanol

Sources & evidence

ORD record
ord-9144ac6f143e4a6986c6144f63eb7a7c
Source dataset
uspto-grants-2010_12
Patent number
US07855214B2

Reaction notes

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